Product Name :
2-Hydroxypropyl-β-cyclodextrin (CAS 128446-35-5)
Synonym :
2-Hydroxypropyl-β-cyclodextrin is also known as Hydroxypropyl-beta-cyclodextrin.
Application :
2-Hydroxypropyl-β-cyclodextrin is a cyclodextrin oligosaccharide that improves the aqueous solubility of various compounds, especially those containing a phenyl group.
CAS:
128446-35-5
Purity:
≥98%
Molecular Weight:
1541.54
Formula :
C63H12O42
Physical state:
Solid
solubility :
Soluble in water (100 mM).
Shipping Condition :
Store at room temperature
Melting point:
305° C
SMILES:
CC(COCC1C2C(C(C(O1)OC3C(OC(C(C3OCC(C)O)OCC(C)O)OC4C(OC(C(C4OCC(C)O)OCC(C)O)OC5C(OC(C(C5OCC(C)O)OCC(C)O)OC6C(OC(C(C6OCC(C)O)OCC(C)O)OC7C(OC(C(C7OCC(C)O)OCC(C)O)OC8C(OC(O2)C(C8OCC(C)O)OCC(C)O)COCC(C)O)COCC(C)O)COCC(C)O)COCC(C)O)COCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)O
References:
:Characterization of the interaction of 2-hydroxypropyl-beta-cyclodextrin with itraconazole at pH 2, 4, and 7.Bis(benzonitrile)palladium chloride Chemscene | Peeters, J., et al. 2002. J Pharm Sci. 91: 1414-22. PMID: 12115841Hydroxypropyl-beta-cyclodextrin can modulate the activity of spinally administered sufentanil. | Meert, TF., et al. 1992. Eur J Anaesthesiol. 9: 399-409. PMID: 1396627Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-beta-cyclodextrin inclusion complex. | de Araujo, DR., et al. 2008. Eur J Pharm Sci. 33: 60-71. PMID: 18036789Structural behaviour of 2-hydroxypropyl-beta-cyclodextrin in water: molecular dynamics simulation studies.1367777-12-5 Chemscene | Yong, CW., et al. 2008. Pharm Res. 25: 1092-9. PMID: 18161014Study of the interaction between hydroxymethylnitrofurazone and 2-hydroxypropyl-beta-cyclodextrin.PMID:33630646 | Grillo, R., et al. 2008. J Pharm Biomed Anal. 47: 295-302. PMID: 18289821Effect of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin complexation on physicochemical properties and antimicrobial activity of cefdinir. | Aleem, O., et al. 2008. J Pharm Biomed Anal. 47: 535-40. PMID: 18367363Comparative interaction of 2-hydroxypropyl-beta-cyclodextrin and sulfobutylether-beta-cyclodextrin with itraconazole: phase-solubility behavior and stabilization of supersaturated drug solutions. | Brewster, ME., et al. 2008. Eur J Pharm Sci. 34: 94-103. PMID: 18420390The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. | Frijlink, HW., et al. 1991. Pharm Res. 8: 380-4. PMID: 2052529Use of 2-hydroxypropyl-beta-cyclodextrin as a solubilizing and stabilizing excipient for protein drugs. | Brewster, ME., et al. 1991. Pharm Res. 8: 792-5. PMID: 2062811Collaborative development of 2-hydroxypropyl- beta -cyclodextrin for the treatment of Niemann-Pick type C1 disease. | Ottinger, EA., et al. 2014. Curr Top Med Chem. 14: 330-9. PMID: 242839702-Hydroxypropyl- beta -cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. | Song, W., et al. 2014. J Biol Chem. 289: 10211-22. PMID: 245580442-Hydroxypropyl- beta -Cyclodextrin Acts as a Novel Anticancer Agent. | Yokoo, M., et al. 2015. PLoS One. 10: e0141946. PMID: 265359092-Hydroxypropyl- beta -Cyclodextrin Aggregates: Identification and Development of Analytical Techniques. | Sá Couto, AR., et al. 2018. Materials (Basel). 11: PMID: 30322145The mechanism of bensulfuron-methyl complexation with beta -cyclodextrin and 2-hydroxypropyl- beta -cyclodextrin and effect on soil adsorption and bio-activity. | Geng, Q., et al. 2019. Sci Rep. 9: 1882. PMID: 30760785Ultrasound processed cuminaldehyde/2-hydroxypropyl- beta -cyclodextrin inclusion complex: Preparation, characterization and antibacterial activity. | Cui, H., et al. 2019. Ultrason Sonochem. 56: 84-93. PMID: 31101292