Postoperative wounds, donor and graft sites and traumatic wounds. Diabetic and infected wounds. To prevent postoperative adhesions in thyroid and spine surgeries. Very good for higher exuding wounds e.g., ulcers such as diabetic and leg stress ulcers. It eliminates odour and ideal for necrotic wounds and wounds with odours. Complete and partialthickness wounds, for ulcers like pressure ulcers, venous ulcers, diabetic ulcers and seconddegree burns. Utilized for ulcers, diabetic wounds, pressure sores, ischemic, necrotic wounds. Utilized to cease bleeding in postoperative wounds, traumatic wounds, gun shots, skin graft donor web pages, bleeding from accidents.
Int. J. Mol. Sci. 2013, 14, 1575515766; doi:ten.3390/ijmsOPEN ACCESSInternational Journal ofMolecular SciencesISSN 14220067 www.mdpi.com/journal/ijms ArticleGalactosylated Chitosan Oligosaccharide Nanoparticles for Hepatocellular Carcinoma CellTargeted Delivery of Adenosine TriphosphateXiu Liang Zhu 1,, Yong Zhong Du 2,, Ri Sheng Yu 1,, Ping Liu two, Dan Shi 1, Ying Chen 1, Ying Wang 1 and Fang Fang HuangDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University College of Medicine, 88 Jiefang Road, Hangzhou 310009, China; EMails: [email protected] (X.L.Z.); [email protected] (D.S.); [email protected] (Y.C.); [email protected] (Y.W.); [email protected] (F.F.H.) Division of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China; EMails: [email protected] (Y.Z.D.); [email protected] (P.L.) These authors contributed equally to this operate. Author to whom correspondence must be addressed; E-mail: [email protected]; Tel./Fax: 8657188208439. Received: 27 April 2013; in revised form: 7 July 2013 / Accepted: 23 July 2013 / Published: 29 JulyAbstract: Nanoparticles composed of galactosylated chitosan oligosaccharide (GalCSO) and adenosine triphosphate (ATP) were prepared for hepatocellular carcinoma cellspecific uptake, and also the traits of GalCSO/ATP nanoparticles have been evaluated.5,6-Diiodobenzo[d][1,3]dioxole uses CSO/ATP nanoparticles had been ready as a manage.2621939-48-6 manufacturer The average diameter and zeta possible of GalCSO/ATP nanoparticles have been 51.PMID:33675514 03 three.26 nm and 30.50 1.25 mV, respectively, suggesting suitable properties for a drug delivery system. Subsequently, the cytotoxicity of GalCSO/ATP nanoparticles were examined by the methyl tetrazolium (MTT) assay, along with the half maximal inhibitory concentration (IC50) values have been calculated with HepG2 (human hepatocellular carcinoma cell line) cells. The results showed that the cytotoxic effect of nanoparticles on HepG2 cells was low. Inside the meantime, it was also located that the GalCSO/ATP nanoparticles may be uptaken by HepG2 cells, on account of expression of the asialoglycoprotein receptor (ASGPR) on their surfaces. The presented outcomes indicate that the GalCSO nanoparticles could possibly be incredibly desirable to be used as an intracellular drugInt. J. Mol. Sci. 2013,delivery carrier for hepatocellular carcinoma cell targeting, as a result warranting additional in vivo or clinical investigations. Keyword phrases: galactosylated chitosan oligosaccharide; adenosine triphosphate; nanoparticles; hepatocyte uptake; targeted drug delivery1. Introduction Resulting from the recent advances in material science and nanotechnology within the past few years, nanoparticles have come to be very eye-catching for their applications inside the fields of biology, medicine and bioimaging [1]. Nanoparticles can be used to reliably and safely deliver proteins, drugs, vaccines along with other bio.
