Nd authorized the final manuscript. Acknowledgements The authors would like to thank the University of Malaya (Grant PPP: PS238/ 2008C, PS478/2010B, PV073-2011B) along with the Ministry of Greater Education Malaysia (HIR-MOHE: F000002-21001) for financial support for this project. Author information 1 Mushroom Study Centre, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. 2Medical Biotechnology Laboratory, University of Malaya Centre for Proteomics Study (UMCPR), Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.References 1. van Vark LC, Bertrand M, Akkerhuis KM, Brugts JJ, Fox K, Mourad J-J, Boersma E: Angiotensin-converting enzyme inhibitors minimize mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone technique inhibitors involving 158 998 individuals. Eur Heart J 2012, 33:2088?097. two. Erd EG: The ACE and I: how ACE inhibitors came to be. FASEB J 2006, 20(eight):1034?038. three. Flint L: The part of ACE inhibitor therapy in treating cardiovascular illness. Nurs Occasions 2004, one hundred(12):34?six. four. Bhuyan BJ, Mugesh G: Angiotensin converting enzyme inhibitors in the treatment of hypertension. Curr Sci 2011, 101(7):881?87. 5. Ma M-S, Bae IY, Lee HG, Yang C-B: Purification and identification of angiotensin I-converting enzyme inhibitory peptide from buckwheat (Fagopyrum esculentum Moench). Meals Chem 2006, 96(1):36?2. 6. Li G-H, Qu M-R, Wan J-Z, You J-M: Antihypertensive effect of rice protein hydrolysate with in vitro angiotensin I-converting enzyme inhibitory activity in spontaneously hypertensive rats.7-Bromo-1H-pyrazolo[3,4-c]pyridine Chemical name Asia Pac J Clin Nutr 2007, 16(Suppl 1):275?80.(2-Hydroxyethyl)trimethylsilane Formula 7. Rho SJ, Lee J-S, Chung YI, Kim Y-W, Lee HG: Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract. Course of action Biochem 2009, 44:490?93. eight. Lee S-H, Qian Z-J, Kim S-K: A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive impact in spontaneously hypertensive rats. Food Chem 2010, 118:96?02. 9. Gu R-Z, Li C-Y, Liu W-Y, Yi W-X, Cai M-Y: Angiotensin I-converting enzyme inhibitory activity of low-molecular-weight peptides from Atlantic salmon (Salmo salar L.PMID:33652009 ) skin. Food Res Int 2011, 44:1536?540. ten. Tavares T, Contreras MM, Amorim M, Pintado M, Recio I, Malcata FX: Novel whey-derived peptides with inhibitory effect against angiotensinconverting enzyme: In vitro effect and stability to gastrointestinal enzyme. Peptides 2011, 32:1013?019. 11. Miyazawa N, Okazaki M, Ohga S: Antihypertensive impact of Pleurotus nebrodensis in spontaneously hypertensive rats. J Oleo Sci 2008, 57(12):675?81. 12. Tam SC, Yip KP, Fung KP, Chang ST: Hypotensive and renal effects of an extract of the edible mushroom. Life Sci 1986, 38(13):1155?161. 13. Wasser SP: Shiitake. In Encyclopedia of Dietary Supplements. Edited by Coates PM, Blackman MR, Cragg GM, Levine M, Moss J, White JD. USA: Marcel Dekker; 2005:653?64. 14. Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG: Antihypertensive and metabolic effects of complete Maitake mushroom powder and its fractions in two rat strains. Mol Cell Biochem 2002, 237(1):129?36. 15. Hagiwara S-Y, Takahashi M, Shen Y, Kaihou S, Tomiyama T, Yazawa M, Tamai Y, Sin Y, Kazusaka A, Terazawa M: A phytochemical inside the edible Tamogi-take mushroom (Pleurotus cornucopiae), D-Mannitol, inhibits ACE activity and lowers the blood pressure of spontaneously hype.